| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 7 |
|---|
| Ligand | BDBM427673 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays |
|---|
| IC50 | 3.90±n/a nM |
|---|
| Citation |  Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 7 |
|---|
| Name: | Toll-like receptor 7 |
|---|
| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 120945.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NYK1 |
|---|
| Residue: | 1049 |
|---|
| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
|
|
|
|---|
| BDBM427673 |
|---|
| n/a |
|---|
| Name | BDBM427673 |
|---|
| Synonyms: | 1-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-pyrrolo[3,2-b]pyridin-5-yl)piperazin-1-yl)-2-methylpropan-2-ol | US10544143, Example 105 | US10730877, Example 105 | US11053244, Example 105 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H35N7O |
|---|
| Mol. Mass. | 461.6024 |
|---|
| SMILES | CC(C)c1c([nH]c2ccc(nc12)N1CCN(CC(C)(C)O)CC1)-c1cn2ncnc2c(C)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
