Ki Summary

Reaction Details

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Target

Toll-like receptor 7

Ligand

BDBM427762

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

0.160±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 7

Name:

Toll-like receptor 7

Synonyms:

ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)

Type:

Enzyme

Mol. Mass.:

120945.35

Organism:

Homo sapiens (Human)

Description:

Q9NYK1

Residue:

1049

Sequence:

MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV

BDBM427762

n/a

Name

BDBM427762

Synonyms:

US10544143, Example 195 | US10544143, Example 199

Type

Small organic molecule

Emp. Form.

C27H34N6O

Mol. Mass.

458.5985

SMILES

COc1cc(cn2ncnc12)-c1[nH]c2ccc(nc2c1C(C)C)C1CCC(CC1)N1CCCC1 |(9.38,.97,;7.84,.97,;7.07,-.36,;5.53,-.36,;4.76,-1.69,;5.53,-3.03,;7.07,-3.03,;8.1,-4.17,;9.51,-3.55,;9.35,-2.01,;7.84,-1.69,;3.22,-1.69,;2.31,-2.94,;.85,-2.46,;-.48,-3.23,;-1.82,-2.46,;-1.82,-.92,;-.48,-.15,;.85,-.92,;2.31,-.45,;2.71,1.04,;1.62,2.13,;4.2,1.44,;-3.15,-.15,;-4.49,-.92,;-5.82,-.15,;-5.82,1.39,;-4.49,2.16,;-3.15,1.39,;-7.15,2.16,;-7.14,3.7,;-8.6,4.17,;-9.51,2.93,;-8.6,1.68,)|

Structure