Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Toll-like receptor 7 | ||
Ligand | BDBM427896 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays | ||
IC50 | 0.140±n/a nM | ||
Citation | Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Toll-like receptor 7 | |||
Name: | Toll-like receptor 7 | ||
Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) | ||
Type: | Enzyme | ||
Mol. Mass.: | 120945.35 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NYK1 | ||
Residue: | 1049 | ||
Sequence: |
| ||
BDBM427896 | |||
n/a | |||
Name | BDBM427896 | ||
Synonyms: | US10544143, Example 330 | US10544143, Example 331 | US10730877, Example 331 | US11053244, Example 331 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H36N6O2 | ||
Mol. Mass. | 488.6244 | ||
SMILES | COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N(C)C1COC1 |(9.81,1.21,;8.27,1.21,;7.5,-.12,;5.96,-.12,;5.19,-1.46,;5.96,-2.79,;7.5,-2.79,;8.53,-3.93,;9.94,-3.31,;9.78,-1.78,;8.27,-1.46,;3.65,-1.46,;2.75,-2.7,;1.28,-2.23,;-.05,-3,;-1.39,-2.23,;-2.72,-3,;-1.39,-.69,;-.05,.08,;1.28,-.69,;2.75,-.21,;3.15,1.28,;2.06,2.37,;4.63,1.68,;-2.72,.08,;-4.05,-.69,;-5.39,.08,;-5.39,1.62,;-4.05,2.39,;-2.72,1.62,;-6.72,2.39,;-6.72,3.93,;-8.05,1.62,;-9.54,2.02,;-9.94,.54,;-8.45,.14,)| | ||
Structure |