Reaction Details | |||
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Report a problem with these data | |||
Target | Toll-like receptor 7 | ||
Ligand | BDBM428604 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays | ||
IC50 | 0.170±n/a nM | ||
Citation | Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Toll-like receptor 7 | |||
Name: | Toll-like receptor 7 | ||
Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) | ||
Type: | Enzyme | ||
Mol. Mass.: | 120945.35 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NYK1 | ||
Residue: | 1049 | ||
Sequence: |
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BDBM428604 | |||
n/a | |||
Name | BDBM428604 | ||
Synonyms: | US10544143, Example 1040 | US10544143, Example 1052 | US10730877, Example 1052 | US11053244, Example 1052 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H38N6 | ||
Mol. Mass. | 470.6522 | ||
SMILES | CC(C)c1c([nH]c2ccc(nc12)C1CCC(CC1)N1CC(C)(C)C1)-c1cn2ncnc2c(C)c1C |(4.74,1.33,;3.25,.93,;2.16,2.02,;2.85,-.56,;3.76,-1.8,;2.85,-3.05,;1.39,-2.57,;.05,-3.34,;-1.28,-2.57,;-1.28,-1.03,;.05,-.26,;1.39,-1.03,;-2.62,-.26,;-2.62,1.28,;-3.95,2.05,;-5.28,1.28,;-5.28,-.26,;-3.95,-1.03,;-6.62,2.05,;-7.02,3.53,;-8.5,3.14,;-10.04,3.14,;-9.27,4.47,;-8.1,1.65,;5.3,-1.8,;6.07,-.47,;7.61,-.47,;8.64,.68,;10.04,.05,;9.88,-1.48,;8.38,-1.8,;7.61,-3.14,;8.38,-4.47,;6.07,-3.14,;5.3,-4.47,)| | ||
Structure |