Reaction Details | |||
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Report a problem with these data | |||
Target | Toll-like receptor 7 | ||
Ligand | BDBM428633 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays | ||
IC50 | 0.090±n/a nM | ||
Citation | Dyckman, AJ; Dodd, DS; Mussari, CP; Kumar, SR 4-azaindole compounds US Patent US10544143 Publication Date 1/28/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Toll-like receptor 7 | |||
Name: | Toll-like receptor 7 | ||
Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) | ||
Type: | Enzyme | ||
Mol. Mass.: | 120945.35 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9NYK1 | ||
Residue: | 1049 | ||
Sequence: |
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BDBM428633 | |||
n/a | |||
Name | BDBM428633 | ||
Synonyms: | US10544143, Example 1069 | US10544143, Example 1070 | US10730877, Example 1070 | US11053244, Example 1070 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H36N6O2 | ||
Mol. Mass. | 500.6351 | ||
SMILES | COc1cc(cn2ncnc12)-c1[nH]c2ccc(nc2c1C(C)C)C1CCC(CC1)N1CC2(C1)CCOC2 |(10.81,1.71,;9.27,1.71,;8.5,.38,;6.96,.38,;6.19,-.96,;6.96,-2.29,;8.5,-2.29,;9.53,-3.44,;10.93,-2.81,;10.77,-1.28,;9.27,-.96,;4.65,-.96,;3.74,-2.2,;2.28,-1.73,;.94,-2.5,;-.39,-1.73,;-.39,-.19,;.94,.58,;2.28,-.19,;3.74,.29,;4.14,1.78,;5.63,2.17,;3.05,2.87,;-1.88,.21,;-2.28,1.7,;-3.76,2.1,;-4.85,1.01,;-4.45,-.48,;-2.97,-.88,;-6.34,1.41,;-7.11,2.74,;-8.44,1.97,;-7.67,.64,;-9.69,1.07,;-10.93,1.97,;-10.46,3.44,;-8.92,3.44,)| | ||
Structure |