| Reaction Details |
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 | Report a problem with these data |
| Target | Kinase suppressor of Ras 2 |
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| Ligand | BDBM50095227 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ATP-Biotin Probe Labeling and Inhibitor Competition |
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| IC50 | 602±205 nM |
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| Citation |  Dar, A; Dhawan, N; Scopton, AP KSR antagonists US Patent US10548897 Publication Date 2/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinase suppressor of Ras 2 |
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| Name: | Kinase suppressor of Ras 2 |
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| Synonyms: | KSR2 | KSR2_HUMAN | hKSR2 |
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| Type: | Protein |
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| Mol. Mass.: | 107668.89 |
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| Organism: | Human |
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| Description: | Q6VAB6 |
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| Residue: | 950 |
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| Sequence: | MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
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| BDBM50095227 |
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| n/a |
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| Name | BDBM50095227 |
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| Synonyms: | (6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)-amine | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine | CHEMBL97771 | US10548897, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19N3O3 |
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| Mol. Mass. | 373.4046 |
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| SMILES | COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC |
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| Structure | 
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