| Reaction Details |
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 | Report a problem with these data |
| Target | Neuroepithelial cell-transforming gene 1 protein |
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| Ligand | BDBM50337822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Functional Uptake Assay (hNET) |
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| IC50 | 790±n/a nM |
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| Citation |  Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent US10562878 Publication Date 2/18/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuroepithelial cell-transforming gene 1 protein |
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| Name: | Neuroepithelial cell-transforming gene 1 protein |
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| Synonyms: | ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67762.41 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118125 |
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| Residue: | 596 |
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| Sequence: | MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPN
WDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTI
QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIY
EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT
KPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSR
KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES
ECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNE
RHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHT
LQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRAST
VSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
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| BDBM50337822 |
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| n/a |
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| Name | BDBM50337822 |
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| Synonyms: | 4-((1-(3,4-dichlorophenyl)cyclohexyl)methyl)morpholine | CHEMBL1683879 | US10562878, Compound 110 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23Cl2NO |
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| Mol. Mass. | 328.277 |
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| SMILES | Clc1ccc(cc1Cl)C1(CN2CCOCC2)CCCCC1 |
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| Structure | 
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