| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase TXK |
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| Ligand | BDBM434515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assay |
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| EC50 | <10±n/a nM |
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| Citation |  Laurent, A; Rose, Y; Morris, SJ Benzimidazoles derivatives as Tec kinases family inhibitors US Patent US10562893 Publication Date 2/18/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase TXK |
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| Name: | Tyrosine-protein kinase TXK |
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| Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
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| Type: | Protein |
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| Mol. Mass.: | 61268.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P42681 |
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| Residue: | 527 |
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| Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
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| BDBM434515 |
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| n/a |
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| Name | BDBM434515 |
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| Synonyms: | US10562893, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31F2N5O2S |
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| Mol. Mass. | 551.651 |
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| SMILES | C[C@H](NCc1ccc2n(c(NC(=O)c3ccc(s3)C(F)F)nc2c1)-c1cccc(NC(=O)C=C)c1)C(C)(C)C |r| |
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| Structure | 
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