| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
|---|
| Ligand | BDBM435264 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Activity Assay |
|---|
| IC50 | 992±n/a nM |
|---|
| Citation |  Imbriglio, J; Liang, R; London, C; Marby, K; Tata, J; You, M; Xiong, Y Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US10568876 Publication Date 2/25/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 2 |
|---|
| Name: | Diacylglycerol O-acyltransferase 2 |
|---|
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 43848.90 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96PD7 |
|---|
| Residue: | 388 |
|---|
| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
|
|
|---|
| BDBM435264 |
|---|
| n/a |
|---|
| Name | BDBM435264 |
|---|
| Synonyms: | N-(tert-butyl)-5-(5- (hydroxymethyl)pyridin-3-yl)-8- (((trans)-2- phenylcyclopropanrcarboxamido) methyl)-3,4-dihydroisoquinoline-2(1H)- carboxamide (mixture of 2 isomers) | US10568876, Example 28 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H36N4O3 |
|---|
| Mol. Mass. | 512.6425 |
|---|
| SMILES | CC(C)(C)NC(=O)N1CCc2c(C1)c(CNC(=O)C1C[C@H]1c1ccccc1)ccc2-c1cncc(CO)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
