| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] |
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| Ligand | BDBM50246927 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 8.00±n/a nM |
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| Citation |  Collins, MR; Kania, RS; Kumpf, RA; Kung, P; Richter, DT; Sutton, SC; Wythes, MJ Substituted dihydroisoquinolinone compounds US Patent US10570121 Publication Date 2/25/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] |
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| Name: | Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] |
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| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641N) | KMT6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 85187.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q15910 Y641N |
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| Residue: | 745 |
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| Sequence: | GQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWK
QRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFM
VEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQY
NDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELK
EKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHA
TPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNN
SSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMK
PNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAP
AEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQN
FCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSC
KNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISENCGEIISQDEADRRGKVYDKY
MCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEE
LFFDYRYSQADALKYVGIEREMEIP
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| BDBM50246927 |
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| n/a |
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| Name | BDBM50246927 |
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| Synonyms: | CHEMBL4060447 | US10570121, Example 127 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26Cl2N2O5 |
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| Mol. Mass. | 481.369 |
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| SMILES | COC(C1CCOC1)c1cc(Cl)c2CCN(Cc3c(OC)cc(C)[nH]c3=O)C(=O)c2c1Cl |
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| Structure | 
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