Reaction Details |
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Target | Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] |
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Ligand | BDBM50246929 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biological Assay |
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IC50 | 5130±n/a nM |
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Citation | Collins, MR; Kania, RS; Kumpf, RA; Kung, P; Richter, DT; Sutton, SC; Wythes, MJ Substituted dihydroisoquinolinone compounds US Patent US10570121 Publication Date 2/25/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] |
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Name: | Histone-lysine N-methyltransferase EZH2 [2-746,Y641N] |
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641N) | KMT6 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 85187.58 |
Organism: | Homo sapiens (Human) |
Description: | Q15910 Y641N |
Residue: | 745 |
Sequence: | GQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWK
QRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFM
VEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQY
NDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELK
EKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHA
TPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNN
SSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMK
PNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAP
AEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQN
FCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSC
KNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISENCGEIISQDEADRRGKVYDKY
MCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEE
LFFDYRYSQADALKYVGIEREMEIP
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BDBM50246929 |
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n/a |
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Name | BDBM50246929 |
Synonyms: | CHEMBL4083256 | US10570121, Example 159 |
Type | Small organic molecule |
Emp. Form. | C23H26Cl2N2O5S |
Mol. Mass. | 513.434 |
SMILES | CCOC(C1CS(=O)(=O)C1)c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl |
Structure |
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