Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHistone-lysine N-methyltransferase EZH2 [2-746,Y641N]
LigandBDBM435691
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 1.000±n/a nM
Citation Collins, MRKania, RSKumpf, RAKung, PRichter, DTSutton, SCWythes, MJ Substituted dihydroisoquinolinone compounds US Patent US10570121 Publication Date 2/25/2020
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase EZH2 [2-746,Y641N]
Name:Histone-lysine N-methyltransferase EZH2 [2-746,Y641N]
Synonyms:EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641N) | KMT6
Type:Enzyme Catalytic Domain
Mol. Mass.:85187.58
Organism:Homo sapiens (Human)
Description:Q15910 Y641N
Residue:745
Sequence:
GQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWK
QRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFM
VEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQY
NDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELK
EKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHA
TPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNN
SSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMK
PNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAP
AEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQN
FCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSC
KNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISENCGEIISQDEADRRGKVYDKY
MCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEE
LFFDYRYSQADALKYVGIEREMEIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM435691
n/a
NameBDBM435691
Synonyms:US10570121, Example 197 | US10570121, Example 198
TypeSmall organic molecule
Emp. Form.C23H27ClN2O4
Mol. Mass.430.924
SMILESCOc1cc(C)[nH]c(=O)c1CN1CCc2c(C)cc(C(C)C3COC3)c(Cl)c2C1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: