Reaction Details |
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Target | Sigma intracellular receptor 2 |
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Ligand | BDBM349543 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Competitive Radioligand Binding Assay |
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Ki | 57.0±n/a nM |
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Citation | Rishton, GM; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent US10611728 Publication Date 4/7/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Sigma intracellular receptor 2 |
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Name: | Sigma intracellular receptor 2 |
Synonyms: | MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97 |
Type: | Protein |
Mol. Mass.: | 20857.20 |
Organism: | Homo sapiens (Human) |
Description: | Q5BJF2 |
Residue: | 176 |
Sequence: | MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQ
EPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLF
EDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
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BDBM349543 |
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n/a |
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Name | BDBM349543 |
Synonyms: | US10207991, Ex. Cpd. No. 59 | US10611728, Example Compound 59 | US11691947, Example 59 |
Type | Small organic molecule |
Emp. Form. | C26H36N2O3 |
Mol. Mass. | 424.5756 |
SMILES | CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(C)(C)C)c1 |
Structure |
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