| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
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| Ligand | BDBM436611 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Ki | 300±n/a nM |
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| Citation |  Cuevas-Cordobés, F; Almansa-Rosales, C Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions US Patent US10590140 Publication Date 3/17/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
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| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
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| Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (aa 25-1103) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 122113.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 25-1103 |
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| Residue: | 1079 |
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| Sequence: | EPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAAR
DIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQR
IKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLL
WQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSV
SGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNN
ITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRV
FTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQV
QWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRF
TLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDA
ELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLP
TYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFN
EFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVY
PKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQG
KLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANH
DDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSV
ADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFD
NDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPC
DMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
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| BDBM436611 |
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| n/a |
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| Name | BDBM436611 |
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| Synonyms: | 2-methoxy-9-methyl- 6-(4-(3- (methylamino)-1- (thiophen-3- yl)propoxy)benzyl)- 6,7,8,9-tetrahydro- 5H-pyrimido[4,5- e][1,4]diazepin-5-one | US10590140, Example 387 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N5O3S |
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| Mol. Mass. | 467.584 |
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| SMILES | CNCCC(Oc1ccc(CN2CCN(C)c3nc(OC)ncc3C2=O)cc1)c1ccsc1 |
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| Structure | 
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