Reaction Details |
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Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
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Ligand | BDBM436623 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | 300±n/a nM |
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Citation | Cuevas-Cordobés, F; Almansa-Rosales, C Tetrahydropyrimidodiazepine and dihydropyridodiazepine compounds for treating pain and pain related conditions US Patent US10590140 Publication Date 3/17/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
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Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103] |
Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (aa 25-1103) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 122113.98 |
Organism: | Homo sapiens (Human) |
Description: | aa 25-1103 |
Residue: | 1079 |
Sequence: | EPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAAR
DIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQR
IKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLL
WQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSV
SGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNN
ITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRV
FTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQV
QWTNVYLDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRF
TLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRPNIQNPKSQEPVTLDFLDA
ELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLP
TYSFYYIKAKLEETITQARYSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFN
EFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVY
PKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQG
KLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANH
DDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSV
ADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFD
NDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPNPC
DMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL
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BDBM436623 |
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n/a |
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Name | BDBM436623 |
Synonyms: | (S)-9-fluoro-1- methyl-4-(4-(3- (methylamino)-1- (thiophen-2- yl)propoxy)benzyl)- 1,2,3,4-tetrahydro- 5H-pyrido[4,3- e][1,4]diazepin-5-one | US10590140, Example 399 |
Type | Small organic molecule |
Emp. Form. | C24H27FN4O2S |
Mol. Mass. | 454.56 |
SMILES | CNCC[C@H](Oc1ccc(CN2CCN(C)c3c(F)cncc3C2=O)cc1)c1cccs1 |r| |
Structure |
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