| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1 |
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| Ligand | BDBM385540 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Affinity Assay |
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| IC50 | <20±n/a nM |
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| Citation |  Musicki, B; Bhurruth-Alcor, Y Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies US Patent US10647706 Publication Date 5/12/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 1 |
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| Name: | C-X-C chemokine receptor type 1 |
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| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39803.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25024 |
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| Residue: | 350 |
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| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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| BDBM385540 |
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| n/a |
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| Name | BDBM385540 |
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| Synonyms: | 3-{4-Chloro-2-hydroxy-3-methane[(N-methyl)sulfoximino]phenylamino}-4-[(R)-1-(5-methylfuran-2-yl)propylamino]cyclobut-3-ene-1,2-dione | US10287278, Example 2 | US10287278, Example 20B: | US10647706, Example 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22ClN3O5S |
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| Mol. Mass. | 451.924 |
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| SMILES | CC[C@@H](Nc1c(Nc2ccc(Cl)c(c2O)S(C)(=O)=NC)c(=O)c1=O)c1ccc(C)o1 |r| |
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| Structure | 
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