| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM442924 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| EC50 | 3.00±n/a nM |
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| Citation |  Kc, SK; Mak, CC; Hofilena, BJ; Mittapalli, GK; Eastman, BW; Cao, J; Bollu, V; Chiruta, C 6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof US Patent US10653688 Publication Date 5/19/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM442924 |
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| n/a |
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| Name | BDBM442924 |
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| Synonyms: | US10653688, Compound 103 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21FN6O |
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| Mol. Mass. | 392.4294 |
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| SMILES | FC1(CNc2cncc(n2)-c2ccc3cnc(NC(=O)C4CC4)cc3c2)CNC1 |
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| Structure | 
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