Ki Summary

Reaction Details

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Target

Monoacylglycerol lipase ABHD6

Ligand

BDBM444468

Substrate/Competitor

n/a

Meas. Tech.

Fluorescent Assay

IC50

55±n/a nM

Citation

Makriyannis, A; Malamas, M; Lamani, M; Farah, SI ABHD6 and dual ABHD6/MGL inhibitors and their uses US Patent US10662159 Publication Date 5/26/2020

More Info.:

Get all data from this article, Assay Method

Monoacylglycerol lipase ABHD6

Name:

Monoacylglycerol lipase ABHD6

Synonyms:

2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6

Type:

PROTEIN

Mol. Mass.:

38341.83

Organism:

Homo sapiens (Human)

Description:

ChEMBL_105457

Residue:

337

Sequence:

MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYST
DNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
NFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVEL
LENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD

BDBM444468

n/a

Name

BDBM444468

Synonyms:

US10662159, Example 58

Type

Small organic molecule

Emp. Form.

C17H16F7NO3

Mol. Mass.

415.3027

SMILES

Fc1cccc(OC2C[C@@]3(C2)CCN(C3)C(=O)OC(C(F)(F)F)C(F)(F)F)c1 |r,wD:9.8,(-17.05,-2.89,;-15.52,-3.05,;-14.89,-4.46,;-13.36,-4.62,;-12.46,-3.38,;-13.08,-1.97,;-12.18,-.72,;-10.65,-.88,;-9.45,.08,;-8.48,-1.11,;-9.68,-2.08,;-7.71,-2.45,;-6.2,-2.13,;-6.04,-.59,;-7.45,.03,;-4.71,.18,;-3.38,-.59,;-4.71,1.72,;-3.38,2.49,;-3.38,4.03,;-3.38,5.57,;-1.84,4.03,;-4.92,4.03,;-2.04,1.72,;-2.81,.38,;-1.27,3.05,;-.71,.95,;-14.62,-1.81,)|

Structure