Ki Summary

Reaction Details

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Target

Monoacylglycerol lipase ABHD6

Ligand

BDBM444474

Substrate/Competitor

n/a

Meas. Tech.

Fluorescent Assay

IC50

55±n/a nM

Citation

Makriyannis, A; Malamas, M; Lamani, M; Farah, SI ABHD6 and dual ABHD6/MGL inhibitors and their uses US Patent US10662159 Publication Date 5/26/2020

More Info.:

Get all data from this article, Assay Method

Monoacylglycerol lipase ABHD6

Name:

Monoacylglycerol lipase ABHD6

Synonyms:

2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6

Type:

PROTEIN

Mol. Mass.:

38341.83

Organism:

Homo sapiens (Human)

Description:

ChEMBL_105457

Residue:

337

Sequence:

MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYST
DNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
NFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVEL
LENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD

BDBM444474

n/a

Name

BDBM444474

Synonyms:

US10662159, Example 67 | US10662159, Example 68

Type

Small organic molecule

Emp. Form.

C24H21F8NO3

Mol. Mass.

523.4157

SMILES

Fc1ccc(cc1)C(OC1CC2(C1)CCN(C2)C(=O)OC(C(F)(F)F)C(F)(F)F)c1ccc(F)cc1 |(-8.79,-.56,;-7.25,-.56,;-6.48,-1.9,;-4.94,-1.9,;-4.17,-.56,;-4.94,.77,;-6.48,.77,;-2.63,-.56,;-1.86,.77,;-.32,.77,;.77,-.32,;1.86,.77,;.77,1.86,;2.76,2.02,;4.23,1.54,;4.23,,;2.76,-.48,;5.47,-.91,;5.31,-2.44,;6.88,-.28,;8.13,-1.18,;9.53,-.56,;10.94,.07,;8.91,.85,;10.16,-1.96,;7.97,-2.72,;7.81,-4.25,;6.43,-2.55,;9.5,-2.88,;-1.86,-1.9,;-.32,-1.9,;.45,-3.23,;-.32,-4.56,;.45,-5.9,;-1.86,-4.56,;-2.63,-3.23,)|

Structure