| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/potassium-transporting ATPase subunit alpha-2/beta-2 |
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| Ligand | BDBM231660 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Selective Inhibition Assays of Isolated Na,K-ATPase |
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| Ki | 20.4±1.8 nM |
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| Citation |  Karlish, SJ; Katz, A; Tal, DM; Marcovich, A Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure US Patent US10668094 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/potassium-transporting ATPase subunit alpha-2/beta-2 |
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| Name: | Sodium/potassium-transporting ATPase subunit alpha-2/beta-2 |
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| Synonyms: | Na,K-ATPase alpha2beta2 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Sodium/potassium-transporting ATPase subunit alpha-2 |
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| Synonyms: | AT1A2_HUMAN | ATP1A2 | KIAA0778 | Na,K-ATPase isoform alpha-2 (α2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 112253.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50993 |
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| Residue: | 1020 |
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| Sequence: | MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG
LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME
DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA
EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI
CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL
GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS
RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF
NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQNAYM
ELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV
GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKAC
VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP
ALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN
IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDK
LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYG
QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA
LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
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| Component 2 |
| Name: | Sodium/potassium-transporting ATPase subunit beta-2 |
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| Synonyms: | AMOG | AT1B2_HUMAN | ATP1B2 | Adhesion molecule in glia | Sodium/potassium-dependent ATPase subunit beta-2 |
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| Type: | Protein |
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| Mol. Mass.: | 33373.25 |
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| Organism: | Human |
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| Description: | P14415 |
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| Residue: | 290 |
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| Sequence: | MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW
VMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDS
IQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFI
KMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYT
QPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT
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| BDBM231660 |
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| n/a |
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| Name | BDBM231660 |
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| Synonyms: | DMe (11) | US10668094, Compound DMe |
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| Type | Small organic molecule |
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| Emp. Form. | C42H67NO12 |
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| Mol. Mass. | 777.9809 |
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| SMILES | C[C@@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]1C[C@H](O)[C@H](OC2CCN(C)CC(C)O2)[C@H](C)O1)O[C@H]1CC[C@@]2(C)C(CCC3C2C[C@H](O)[C@]2(C)[C@H](CC[C@]32O)C2=CC(=O)OC2)C1 |r,t:54| |
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| Structure | 
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