| Reaction Details |
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 | Report a problem with these data |
| Target | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Ligand | BDBM365353 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PKR KinaseGlo Assay |
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| IC50 | 390±n/a nM |
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| Citation |  Boral, S; Malone, TC; Wang, S Pyridyl benzothiophenes as kinase inhibitors US Patent US10669265 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interferon-induced, double-stranded RNA-activated protein kinase |
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| Name: | Interferon-induced, double-stranded RNA-activated protein kinase |
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| Synonyms: | E2AK2_HUMAN | EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | Interferon-inducible RNA-dependent protein kinase | P1/eIF-2A protein kinase | PKR | PRKR | Protein kinase R | Protein kinase RNA-activated | Tyrosine-protein kinase EIF2AK2 | eIF-2A protein kinase 2 | p68 kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62104.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467743 |
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| Residue: | 551 |
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| Sequence: | MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
KSPEKNERHTC
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| BDBM365353 |
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| n/a |
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| Name | BDBM365353 |
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| Synonyms: | 5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino} carbonyl)amino]-1- benzothien-2-yl}-N- [dimethyl(oxido)-lambda4- sulfanylidene]nicotinamide | US10633373, Example 58 | US10669265, Example 58 | US9868726, Example 58 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18ClF3N4O3S2 |
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| Mol. Mass. | 567.003 |
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| SMILES | CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1 |
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| Structure | 
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