| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor NF-kappa-B p105 subunit |
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| Ligand | BDBM446463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Nuclear Factor of Activated T-Cells (NFAT) Assay |
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| EC50 | 55±n/a nM |
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| Citation |  Wu, L; Li, J; Yao, W Heterocyclic compounds as immunomodulators US Patent US10669271 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor NF-kappa-B p105 subunit |
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| Name: | Nuclear factor NF-kappa-B p105 subunit |
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| Synonyms: | NFKB1 | NFKB1_HUMAN | Nuclear factor NF-kappa-B (NF-kB) | Nuclear factor NF-kappa-B complex | Nuclear factor NF-kappa-B p105 subunit |
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| Type: | Protein |
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| Mol. Mass.: | 105329.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19838 |
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| Residue: | 968 |
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| Sequence: | MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV
CEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCED
GICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQA
EGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDF
SPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQ
RKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFH
PGTTKSNAGMKHGTMDTESKKDPEGCDKSDDKNTVNLFGKVIETTEQDQEPSEATVGNGE
VTLTYATGTKEESAGVQDNLFLEKAMQLAKRHANALFDYAVTGDVKMLLAVQRHLTAVQD
ENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVED
LLRAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMM
SNSLPCLLLLVAAGADVNAQEQKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGT
TPLHIAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMAT
SWQVFDILNGKPYEPEFTSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLG
LGILNNAFRLSPAPSKTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQ
AHSLPLSPASTRQQIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQ
EGPLEGKI
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| BDBM446463 |
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| n/a |
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| Name | BDBM446463 |
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| Synonyms: | (R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic Acid | US10669271, Example 16 | US10669271, Example 19 | US11124511, Example 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H40F2N8O4 |
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| Mol. Mass. | 758.815 |
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| SMILES | Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C |r| |
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| Structure | 
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