| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM285614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assays |
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| IC50 | 44.4±n/a nM |
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| Citation |  Chappie, TA; Patel, NC; Hayward, MM; Helal, CJ; Sciabola, S; LaChapelle, EA; Young, JM; Verhoest, PR Imidazopyridazine compounds US Patent US10669279 Publication Date 6/2/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 79875.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08493 |
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| Residue: | 712 |
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| Sequence: | MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD
LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF
LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA
AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI
LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA
SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL
KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA
ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL
SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN
LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF
IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL
TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
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| BDBM285614 |
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| n/a |
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| Name | BDBM285614 |
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| Synonyms: | US10077269, Example 84 | US10669279, Example 84 | US9598421, Example 84 | azetidin-1-yl[3-(3-chloro-phenyl)imidazo[1,2-b]pyridazin-2-yl]methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13ClN4O |
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| Mol. Mass. | 312.754 |
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| SMILES | Clc1cccc(c1)-c1c(nc2cccnn12)C(=O)N1CCC1 |
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| Structure | 
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