Reaction Details |
| Report a problem with these data |
Target | Prolyl endopeptidase |
---|
Ligand | BDBM298352 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | POP Inhibition Assays |
---|
IC50 | 60.4±10.6 nM |
---|
Citation | Giralt Lledó, E; Tarragó Clua, T; Prades Cosano, R; Royo Gracia, S 1- [1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives US Patent US10125097 Publication Date 11/13/2018 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prolyl endopeptidase |
---|
Name: | Prolyl endopeptidase |
Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase |
Type: | Enzyme |
Mol. Mass.: | 80688.50 |
Organism: | Homo sapiens (Human) |
Description: | P48147 |
Residue: | 710 |
Sequence: | MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
|
|
|
BDBM298352 |
---|
n/a |
---|
Name | BDBM298352 |
Synonyms: | (S)-1-((2S,4R)-1-(4-(benzyloxy)-3,5-dimethoxybenzoyl)-4-fluoropyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile | US10125097, Example 2 | US10611727, Example 2 |
Type | Small organic molecule |
Emp. Form. | C26H28FN3O5 |
Mol. Mass. | 481.516 |
SMILES | COc1cc(cc(OC)c1OCc1ccccc1)C(=O)N1C[C@H](F)C[C@H]1C(=O)N1CCC[C@H]1C#N |r| |
Structure |
|