| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM446703 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ADP-Glo Kinase Assay |
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| IC50 | 6.69±n/a nM |
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| Citation |  Lau, WC Methods, compositions, and uses of novel Fyn kinase inhibitors US Patent US10688093 Publication Date 6/23/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM446703 |
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| n/a |
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| Name | BDBM446703 |
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| Synonyms: | US10688093, Compound B50 (U.S. Pat. No.-8,492,377)-(Janssen-Pharma-ceuticals) | US11701353, Compound B50 (U.S. Pat. No. 8,492,377) (Janssen Pharmaceuticals) | benzyl- 21-methoxy-5,7,19- trioxa-2,13,24,26- tetraazapenta- cyclo[18.6.2.03, 11.04,8.023,27]octacosa- 1(26),3(11),4(8),9, 20,22,24,27-octaene- 13-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C30H30N4O6 |
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| Mol. Mass. | 542.5824 |
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| SMILES | COc1cc2ncnc3Nc4c5OCOc5ccc4CN(CCCCCOc1cc23)C(=O)OCc1ccccc1 |
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| Structure | 
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