| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fyn |
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| Ligand | BDBM446704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ADP-Glo Kinase Assay |
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| IC50 | 8.00±n/a nM |
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| Citation |  Lau, WC Methods, compositions, and uses of novel Fyn kinase inhibitors US Patent US10688093 Publication Date 6/23/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fyn |
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| Name: | Tyrosine-protein kinase Fyn |
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| Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
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| Type: | Enzyme |
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| Mol. Mass.: | 60762.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06241 |
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| Residue: | 537 |
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| Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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| BDBM446704 |
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| n/a |
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| Name | BDBM446704 |
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| Synonyms: | 9-methoxy-N-{3- methoxy-4-[3- (pyrrolidin-1-yl)propyl] phenyl}-6,6-dimethyl- 5H,6H-benzo[h] quinazolin-2-amine | US10688093, Compound CT5263-(CellTech) | US11701353, CT5263 (CellTech) |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36N4O2 |
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| Mol. Mass. | 472.6217 |
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| SMILES | COc1ccc2c(c1)-c1nc(Nc3ccc(CCCN4CCCC4)c(OC)c3)ncc1CC2(C)C |
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| Structure | 
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