| Reaction Details |
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 | Report a problem with these data |
| Target | SRSF protein kinase 1 |
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| Ligand | BDBM448661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 4.60±n/a nM |
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| Citation |  Bates, D; Morris, J; Toop, H; Batson, J; Morley, AD Compounds US Patent US10696661 Publication Date 6/30/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| SRSF protein kinase 1 |
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| Name: | SRSF protein kinase 1 |
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| Synonyms: | SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1 |
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| Type: | Protein |
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| Mol. Mass.: | 74318.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96SB4 |
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| Residue: | 655 |
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| Sequence: | MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
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| BDBM448661 |
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| n/a |
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| Name | BDBM448661 |
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| Synonyms: | N-(2-(4-(oxazol-2-ylmethyl)piperazin-1-yl)-5- (trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide | US10696661, Compound 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22F3N5O3 |
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| Mol. Mass. | 497.4691 |
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| SMILES | FC(F)(F)c1ccc(N2CCN(Cc3ncco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 |
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| Structure | 
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