| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SRSF protein kinase 1 |
|---|
| Ligand | BDBM448682 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 6.70±n/a nM |
|---|
| Citation |  Bates, D; Morris, J; Toop, H; Batson, J; Morley, AD Compounds US Patent US10696661 Publication Date 6/30/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| SRSF protein kinase 1 |
|---|
| Name: | SRSF protein kinase 1 |
|---|
| Synonyms: | SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74318.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96SB4 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
|
|
|
|---|
| BDBM448682 |
|---|
| n/a |
|---|
| Name | BDBM448682 |
|---|
| Synonyms: | N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (trifluoromethyl)phenyl)-picolinamide | US10696661, Compound 31 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20F3N5OS |
|---|
| Mol. Mass. | 447.477 |
|---|
| SMILES | FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccccn2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
