Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase JAK1 [850-1154]

Ligand

BDBM449876

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

EC50

3.48±n/a nM

Citation

Larsen, J; Larsen, M; Rasmussen, LK; Ritzen, A; Duus, TM Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof US Patent US10703751 Publication Date 7/7/2020

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase JAK1 [850-1154]

Name:

Tyrosine-protein kinase JAK1 [850-1154]

Synonyms:

JAK1 | JAK1 (aa 850-1154) | JAK1A | JAK1B | JAK1_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

34949.64

Organism:

Homo sapiens (Human)

Description:

P23458[850-1154]

Residue:

305

Sequence:

EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS
LKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP
KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFL
KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
EALLK

BDBM449876

n/a

Name

BDBM449876

Synonyms:

US10703751, Example 2 | US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydroxyethyl]-6-(methylamino)imidazo[4,5-c]pyridin-1-yl]cyclo-hexyl]acetonitrile (Compound 2) and trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methyl-amino)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile

Type

Small organic molecule

Emp. Form.

C17H23N5O

Mol. Mass.

313.3974

SMILES

CNc1cc2n([C@H]3CC[C@H](CC#N)CC3)c(nc2cn1)[C@@H](C)O |r,wU:6.5,20.24,wD:9.9,(1.71,-18.63,;3.03,-19.4,;4.36,-18.63,;4.36,-17.09,;5.69,-16.32,;6.01,-14.81,;4.98,-13.67,;3.48,-13.99,;2.45,-12.84,;2.92,-11.38,;1.89,-10.23,;.38,-10.55,;-1.12,-10.87,;4.43,-11.06,;5.46,-12.2,;7.54,-14.65,;8.17,-16.06,;7.03,-17.09,;7.03,-18.63,;5.69,-19.4,;8.31,-13.32,;7.54,-11.98,;9.85,-13.32,)|

Structure