| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 3 |
|---|
| Ligand | BDBM451711 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | 120±n/a nM |
|---|
| Citation |  Gray, NS; Buhrlage, S; Anderson, K; Cottini, F; Tonon, G STK4 inhibitors for treatment of hematologic malignancies US Patent US10710978 Publication Date 7/14/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase 3 |
|---|
| Name: | Serine/threonine-protein kinase 3 |
|---|
| Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 56284.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 491 |
|---|
| Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
|
|
|
|---|
| BDBM451711 |
|---|
| n/a |
|---|
| Name | BDBM451711 |
|---|
| Synonyms: | 6-(2-amino-5-(2-fluoro-5- nitrophenyl)pyridin-3-yl)-3,4- dihydroisoquinolin-1(2H)-one | US10710978, Compound I-1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15FN4O3 |
|---|
| Mol. Mass. | 378.3565 |
|---|
| SMILES | Nc1ncc(cc1-c1ccc2C(=O)NCCc2c1)-c1cc(ccc1F)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
