| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma [262-507] |
|---|
| Ligand | BDBM383125 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Binding Assay |
|---|
| IC50 | 13.0±n/a nM |
|---|
| Citation |  Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Tricyclic sulfones as RORγ modulators US Patent US10711020 Publication Date 7/14/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor ROR-gamma [262-507] |
|---|
| Name: | Nuclear receptor ROR-gamma [262-507] |
|---|
| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 28605.37 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 262-507 |
|---|
| Residue: | 246 |
|---|
| Sequence: | APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFS
|
|
|
|---|
| BDBM383125 |
|---|
| n/a |
|---|
| Name | BDBM383125 |
|---|
| Synonyms: | (1R,2S)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers) | US10273259, Example 836 | US10273259, Example 837 | US10711020, Example 837 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H29F8NO5S |
|---|
| Mol. Mass. | 667.607 |
|---|
| SMILES | C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
