| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
|---|
| Ligand | BDBM454734 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FLIPR Assay in PAR4-Expressing HEK293 Cells |
|---|
| IC50 | 0.460±n/a nM |
|---|
| Citation |  Fu, Q; Zhang, X; Priestley, ES; Halpern, OS; Reznik, SK; Richter, JM Bicyclic heteroaryl substituted compounds US Patent US10730868 Publication Date 8/4/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proteinase-activated receptor 4 |
|---|
| Name: | Proteinase-activated receptor 4 |
|---|
| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41145.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI0 |
|---|
| Residue: | 385 |
|---|
| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
|
|
|
|---|
| BDBM454734 |
|---|
| n/a |
|---|
| Name | BDBM454734 |
|---|
| Synonyms: | US10730868, Ex. No. 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H33F3N6O6S |
|---|
| Mol. Mass. | 710.723 |
|---|
| SMILES | COc1cnc2c(cc(C)cc2n1)-c1nc2cc(F)c(O[C@H]3CC(F)(F)CC[C@H]3OC(=O)Nc3ccc(nc3)C(=O)NCC(C)(C)O)cc2s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
