Ki Summary

Reaction Details

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Target

Toll-like receptor 8

Ligand

BDBM427909

Substrate/Competitor

n/a

Meas. Tech.

TLR7/8/9 Inhibition Reporter Assays

IC50

4.80±n/a nM

Citation

Dyckman, AJ; Dodd, DS; Mussari, CP; Sherwood, TC; Whiteley, BK; Gilmore, JL; Kumar, SR; Pasunoori, L; Srinivas, PV; Duraisamy, SK; Hegde, S; Anumula, RK 4-Azaindole compounds US Patent US10730877 Publication Date 8/4/2020

More Info.:

Get all data from this article, Assay Method

Toll-like receptor 8

Name:

Toll-like receptor 8

Synonyms:

CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8

Type:

Enzyme

Mol. Mass.:

119828.77

Organism:

Homo sapiens (Human)

Description:

Q9NR97

Residue:

1041

Sequence:

MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY

BDBM427909

n/a

Name

BDBM427909

Synonyms:

US10544143, Example 343 | US10544143, Example 344 | US10730877, Example 344 | US11053244, Example 344

Type

Small organic molecule

Emp. Form.

C28H33FN6O2

Mol. Mass.

504.599

SMILES

COc1cc(cn2ncnc12)-c1[nH]c2cc(F)c(nc2c1C(C)C)C1CCC(CC1)N1CC2(COC2)C1 |(10.09,.69,;8.55,.69,;7.78,-.64,;6.24,-.64,;5.47,-1.97,;6.24,-3.31,;7.78,-3.31,;8.81,-4.45,;10.22,-3.83,;10.05,-2.29,;8.55,-1.97,;3.93,-1.97,;3.02,-3.22,;1.56,-2.74,;.22,-3.51,;-1.11,-2.74,;-2.44,-3.51,;-1.11,-1.2,;.22,-.43,;1.56,-1.2,;3.02,-.73,;3.42,.76,;2.33,1.85,;4.91,1.16,;-2.44,-.43,;-3.78,-1.2,;-5.11,-.43,;-5.11,1.11,;-3.78,1.88,;-2.44,1.11,;-6.44,1.88,;-6.84,3.36,;-8.33,2.96,;-8.73,4.45,;-10.22,4.05,;-9.82,2.57,;-7.93,1.48,)|

Structure