| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 8 |
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| Ligand | BDBM428465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TLR7/8/9 Inhibition Reporter Assays |
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| IC50 | 0.150±n/a nM |
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| Citation |  Dyckman, AJ; Dodd, DS; Mussari, CP; Sherwood, TC; Whiteley, BK; Gilmore, JL; Kumar, SR; Pasunoori, L; Srinivas, PV; Duraisamy, SK; Hegde, S; Anumula, RK 4-Azaindole compounds US Patent US10730877 Publication Date 8/4/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 8 |
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| Name: | Toll-like receptor 8 |
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| Synonyms: | CD_antigen: CD288 | TLR8 | TLR8_HUMAN | TRL8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119828.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NR97 |
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| Residue: | 1041 |
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| Sequence: | MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
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| BDBM428465 |
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| n/a |
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| Name | BDBM428465 |
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| Synonyms: | US10544143, Example 901 | US10730877, Example 901 | US11053244, Example 901 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N8O2 |
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| Mol. Mass. | 542.6751 |
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| SMILES | CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| |
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| Structure | 
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