| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclic GMP-AMP synthase [155-522] |
|---|
| Ligand | BDBM457620 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Activity Assay |
|---|
| IC50 | <20±n/a nM |
|---|
| Citation |  Ndubaku, CO; Katibah, GE; Roberts, TC; Sung, L; Ciblat, S; Raeppel, F; Ly, VL; Ramtohul, YK; Rybak, T; Zaky, M; Gillard, L; Ismaili, H Pyrazolopyrimidinone compounds and uses thereof US Patent US10738056 Publication Date 8/11/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclic GMP-AMP synthase [155-522] |
|---|
| Name: | Cyclic GMP-AMP synthase [155-522] |
|---|
| Synonyms: | C6orf150 | CGAS | CGAS_HUMAN | Cyclic GMP-AMP synthase (CGAS) (155-522) | MB21D1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43018.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8N884[155-522] |
|---|
| Residue: | 368 |
|---|
| Sequence: | RRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSY
YEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSAS
KMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPAST
QEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSK
TCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQ
WDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNN
EFPVFDEF
|
|
|
|---|
| BDBM457620 |
|---|
| n/a |
|---|
| Name | BDBM457620 |
|---|
| Synonyms: | US10738056, Compound D1067 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H13F3N6O3 |
|---|
| Mol. Mass. | 454.3615 |
|---|
| SMILES | Cc1[nH]c2c(c(nn2c(=O)c1-c1nnc(o1)-c1cccnc1O)C(F)(F)F)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
