Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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Ligand | BDBM50447214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | UV-vis cuvette-based assay |
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IC50 | 510±n/a nM |
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Citation | Maloney, DJ; Luci, DK; Jadhav, A; Holman, T; Nadler, JL; Holinstat, M; Taylor-Fishwick, D; Simeonov, A; Yasgar, A; McKenzie, S 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase US Patent US10752581 Publication Date 8/25/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX12 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
Type: | Protein |
Mol. Mass.: | 75689.18 |
Organism: | Homo sapiens (Human) |
Description: | P18054 |
Residue: | 663 |
Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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BDBM50447214 |
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n/a |
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Name | BDBM50447214 |
Synonyms: | CHEMBL3113179 | US10752581, Compound 49 |
Type | Small organic molecule |
Emp. Form. | C24H22N2O4S |
Mol. Mass. | 434.507 |
SMILES | COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2cccc3ccccc23)c1O |
Structure |
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