| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Ligand | BDBM50447203 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | UV-vis cuvette-based assay |
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| IC50 | 390±n/a nM |
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| Citation |  Maloney, DJ; Luci, DK; Jadhav, A; Holman, T; Nadler, JL; Holinstat, M; Taylor-Fishwick, D; Simeonov, A; Yasgar, A; McKenzie, S 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase US Patent US10752581 Publication Date 8/25/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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| Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
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| Type: | Protein |
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| Mol. Mass.: | 75689.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18054 |
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| Residue: | 663 |
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| Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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|
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| BDBM50447203 |
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| n/a |
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| Name | BDBM50447203 |
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| Synonyms: | CHEMBL3113191 | US10752581, Compound 61 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O4S |
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| Mol. Mass. | 440.555 |
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| SMILES | COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2cccc(c2)C(C)(C)C)c1O |
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| Structure | 
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