Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM50447182 |
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Substrate/Competitor | n/a |
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Meas. Tech. | UV-vis cuvette-based assay |
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IC50 | 5100±n/a nM |
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Citation | Maloney, DJ; Luci, DK; Jadhav, A; Holman, T; Nadler, JL; Holinstat, M; Taylor-Fishwick, D; Simeonov, A; Yasgar, A; McKenzie, S 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase US Patent US10752581 Publication Date 8/25/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
Type: | Protein |
Mol. Mass.: | 74804.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 662 |
Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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BDBM50447182 |
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n/a |
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Name | BDBM50447182 |
Synonyms: | CHEMBL3113192 | US10752581, Compound 62 |
Type | Small organic molecule |
Emp. Form. | C22H21N3O5S2 |
Mol. Mass. | 471.549 |
SMILES | COc1ccc2nc(NS(=O)(=O)c3ccc(NCc4cccc(OC)c4O)cc3)sc2c1 |
Structure |
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