Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Tec | ||
Ligand | BDBM458162 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Inhibition Assay | ||
IC50 | 0.870±n/a nM | ||
Citation | Laurent, A; Morris, SJ Spirocyclic containing compounds and pharmaceutical uses thereof US Patent US10752615 Publication Date 8/25/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Tec | |||
Name: | Tyrosine-protein kinase Tec | ||
Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) | ||
Type: | Protein | ||
Mol. Mass.: | 73597.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 631 | ||
Sequence: |
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BDBM458162 | |||
n/a | |||
Name | BDBM458162 | ||
Synonyms: | US10752615, Compound 54 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H32N6O4S | ||
Mol. Mass. | 572.678 | ||
SMILES | CC(C)C(=O)N(C)c1ccc2n([C@H]3C[C@]4(C3)CCN(C4)C(=O)C=C)c(NC(=O)c3ccc(s3)-c3cnco3)nc2c1 |r,wU:12.11,14.14,(-10.15,4.58,;-8.81,5.35,;-8.81,6.89,;-7.48,4.58,;-7.48,3.04,;-6.15,5.35,;-6.15,6.89,;-4.81,4.58,;-4.81,3.04,;-3.48,2.27,;-2.15,3.04,;-.68,2.57,;-.28,1.08,;1.05,.31,;.28,-1.03,;-1.05,-.26,;1.75,-1.5,;1.75,-3.04,;.28,-3.52,;-.62,-2.27,;-.12,-5.01,;.97,-6.09,;-1.6,-5.4,;-2,-6.89,;.22,3.81,;1.76,3.81,;2.53,5.14,;1.76,6.48,;4.07,5.14,;4.98,6.39,;6.44,5.91,;6.44,4.37,;4.98,3.9,;7.78,3.6,;9.24,4.08,;10.15,2.83,;9.24,1.59,;7.78,2.06,;-.68,5.06,;-2.15,4.58,;-3.48,5.35,)| | ||
Structure |