Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Tec | ||
Ligand | BDBM458171 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Inhibition Assay | ||
IC50 | 1.10±n/a nM | ||
Citation | Laurent, A; Morris, SJ Spirocyclic containing compounds and pharmaceutical uses thereof US Patent US10752615 Publication Date 8/25/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Tec | |||
Name: | Tyrosine-protein kinase Tec | ||
Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) | ||
Type: | Protein | ||
Mol. Mass.: | 73597.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 631 | ||
Sequence: |
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BDBM458171 | |||
n/a | |||
Name | BDBM458171 | ||
Synonyms: | US10752615, Compound 63 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H22ClN5O3S | ||
Mol. Mass. | 507.992 | ||
SMILES | Clc1ccc2n([C@H]3C[C@]4(C3)CCN(C4)C(=O)C=C)c(NC(=O)c3ccc(s3)-c3cnco3)nc2c1 |r,wU:6.5,8.8,(-8.15,5.56,;-6.81,4.79,;-6.81,3.25,;-5.48,2.48,;-4.15,3.25,;-2.68,2.77,;-2.28,1.28,;-.95,.51,;-1.72,-.82,;-3.05,-.05,;-.25,-1.3,;-.25,-2.84,;-1.72,-3.31,;-2.62,-2.07,;-2.12,-4.8,;-1.03,-5.89,;-3.61,-5.2,;-4,-6.68,;-1.78,4.02,;-.24,4.02,;.53,5.35,;-.24,6.68,;2.07,5.35,;2.98,6.6,;4.44,6.12,;4.44,4.58,;2.98,4.11,;5.78,3.81,;7.24,4.29,;8.15,3.04,;7.24,1.8,;5.78,2.27,;-2.68,5.26,;-4.15,4.79,;-5.48,5.56,)| | ||
Structure |