Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Tec | ||
Ligand | BDBM50458600 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Inhibition Assay | ||
IC50 | 0.090±n/a nM | ||
Citation | Laurent, A; Morris, SJ Spirocyclic containing compounds and pharmaceutical uses thereof US Patent US10752615 Publication Date 8/25/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Tec | |||
Name: | Tyrosine-protein kinase Tec | ||
Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) | ||
Type: | Protein | ||
Mol. Mass.: | 73597.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 631 | ||
Sequence: |
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BDBM50458600 | |||
n/a | |||
Name | BDBM50458600 | ||
Synonyms: | CHEMBL4206765 | US10752615, Compound 97 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H25N5O3S | ||
Mol. Mass. | 499.584 | ||
SMILES | C=CC(=O)N1CC[C@@]2(C[C@@H](C2)n2c(NC(=O)c3ccc(s3)-c3cc[nH]c(=O)c3)nc3ccccc23)C1 |r,wU:7.6,9.11,(11.17,-39.5,;11.5,-38,;12.96,-37.53,;14.1,-38.57,;13.29,-36.02,;14.7,-35.41,;14.55,-33.87,;13.05,-33.54,;13.74,-32.16,;12.37,-31.47,;11.68,-32.85,;11.89,-30.01,;12.79,-28.75,;14.33,-28.74,;15.09,-27.41,;14.32,-26.08,;16.63,-27.39,;17.52,-26.14,;18.98,-26.6,;18.99,-28.14,;17.54,-28.62,;20.24,-29.02,;21.64,-28.38,;22.89,-29.29,;22.74,-30.82,;21.33,-31.45,;21.18,-32.99,;20.08,-30.56,;11.87,-27.5,;10.4,-27.99,;9.06,-27.23,;7.74,-28,;7.73,-29.54,;9.07,-30.31,;10.41,-29.54,;12.27,-34.87,)| | ||
Structure |