Reaction Details | |||
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Report a problem with these data | |||
Target | Tyrosine-protein kinase Tec | ||
Ligand | BDBM458238 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Inhibition Assay | ||
IC50 | 0.080±n/a nM | ||
Citation | Laurent, A; Morris, SJ Spirocyclic containing compounds and pharmaceutical uses thereof US Patent US10752615 Publication Date 8/25/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase Tec | |||
Name: | Tyrosine-protein kinase Tec | ||
Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) | ||
Type: | Protein | ||
Mol. Mass.: | 73597.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 631 | ||
Sequence: |
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BDBM458238 | |||
n/a | |||
Name | BDBM458238 | ||
Synonyms: | US10752615, Compound 136 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H26N6O2S | ||
Mol. Mass. | 522.621 | ||
SMILES | C=CC(=O)N1CC[C@@]2(C[C@@H](C2)n2c(NC(=O)c3ccc(s3)-c3ccnc4[nH]ccc34)nc3ccccc23)C1 |r,wU:9.11,7.10,(-5.39,-6.68,;-4.99,-5.2,;-3.51,-4.8,;-2.42,-5.89,;-3.11,-3.31,;-1.64,-2.84,;-1.64,-1.3,;-3.11,-.82,;-2.34,.51,;-3.67,1.28,;-4.44,-.05,;-4.07,2.77,;-3.16,4.02,;-1.62,4.02,;-.85,5.35,;-1.62,6.68,;.69,5.35,;1.59,6.6,;3.06,6.12,;3.06,4.58,;1.59,4.11,;4.39,3.81,;4.39,2.27,;5.72,1.5,;7.06,2.27,;7.06,3.81,;8.2,4.84,;7.57,6.25,;6.04,6.09,;5.72,4.58,;-4.07,5.26,;-5.53,4.79,;-6.87,5.56,;-8.2,4.79,;-8.2,3.25,;-6.87,2.48,;-5.53,3.25,;-4.01,-2.07,)| | ||
Structure |