| Reaction Details |
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 | Report a problem with these data |
| Target | Cell division cycle 7-related protein kinase/Protein DBF4 homolog A |
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| Ligand | BDBM458732 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | <10000±n/a nM |
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| Citation |  Zhang, H Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents US Patent US10745410 Publication Date 8/18/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cell division cycle 7-related protein kinase/Protein DBF4 homolog A |
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| Name: | Cell division cycle 7-related protein kinase/Protein DBF4 homolog A |
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| Synonyms: | Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase | CDC7 and DBF4 | CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein DBF4 homolog A |
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| Synonyms: | ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1 |
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| Type: | Regulatory subunit |
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| Mol. Mass.: | 76869.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 674 |
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| Sequence: | MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTI
SEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPH
PSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIE
QKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMP
FINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCL
QKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSP
VSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPS
NELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVD
HYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQ
EHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRT
EFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLT
AFFSSPSTSTFTGF
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| Component 2 |
| Name: | Cell division cycle 7-related protein kinase |
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| Synonyms: | CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7 |
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| Type: | Protein |
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| Mol. Mass.: | 63908.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00311 |
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| Residue: | 574 |
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| Sequence: | MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
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| BDBM458732 |
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| n/a |
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| Name | BDBM458732 |
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| Synonyms: | (S)-6-(2-fluoropyridin-4- yl)-2-(2-methyl-1- (methylamino)propyl) thieno[3,2-d]pyrimidin- 4(3H)-one hydrochloride | US10745410, Code 36 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17FN4OS |
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| Mol. Mass. | 332.396 |
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| SMILES | CN[C@@H](C(C)C)c1nc2cc(sc2c(=O)[nH]1)-c1ccnc(F)c1 |r| |
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| Structure | 
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