Reaction Details | |||
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Target | Tyrosine-protein kinase JAK3 [795-1124] | ||
Ligand | BDBM458851 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro JAK kinase Assays | ||
IC50 | 4.00±n/a nM | ||
Citation | Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK3 [795-1124] | |||
Name: | Tyrosine-protein kinase JAK3 [795-1124] | ||
Synonyms: | JAK3 | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (795-1124) | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 37299.74 | ||
Organism: | Homo sapiens (Human) | ||
Description: | aa 795-1124 | ||
Residue: | 330 | ||
Sequence: |
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BDBM458851 | |||
n/a | |||
Name | BDBM458851 | ||
Synonyms: | US10759793, Example 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H33FN8 | ||
Mol. Mass. | 476.5922 | ||
SMILES | CN(C)C1CCN(CC1)c1nc(nc(N[C@H]2CC[C@H](CC#N)CC2)c1F)-c1cnn2ccccc12 |r,wU:18.19,wD:15.15,(-9.78,3.33,;-8.75,4.47,;-9.23,5.94,;-7.25,4.15,;-6.21,5.3,;-4.71,4.98,;-4.23,3.51,;-5.26,2.37,;-6.77,2.69,;-2.73,3.19,;-2.25,1.73,;-.74,1.41,;.29,2.55,;-.19,4.02,;.84,5.16,;2.35,4.84,;2.82,3.38,;4.33,3.06,;5.36,4.2,;6.87,3.88,;7.9,5.02,;8.93,6.17,;4.88,5.67,;3.38,5.99,;-1.7,4.34,;-2.17,5.8,;-.27,-.06,;-1.17,-1.3,;-.27,-2.55,;1.2,-2.07,;2.53,-2.84,;3.86,-2.07,;3.86,-.53,;2.53,.24,;1.2,-.53,)| | ||
Structure |