| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [850-1154] |
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| Ligand | BDBM458861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro JAK kinase Assays |
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| IC50 | 1.000±n/a nM |
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| Citation |  Esteve Trias, C; Taltavull Moll, J; Gonzalez Rodriguez, J; Vidal Juan, B 2-(pyrazolopyridin-3-yl)pyrimidine derivatives as JAK inhibitors US Patent US10759793 Publication Date 9/1/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [850-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [850-1154] |
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| Synonyms: | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (850-1154) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 34949.64 |
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| Organism: | n/a |
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| Description: | aa 850-1154 |
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| Residue: | 305 |
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| Sequence: | EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKS
LKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLP
KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIE
TDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFL
KMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGF
EALLK
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| BDBM458861 |
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| n/a |
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| Name | BDBM458861 |
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| Synonyms: | US10759793, Example 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22FN7O3 |
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| Mol. Mass. | 439.4429 |
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| SMILES | OCCOc1nc(nc(N[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12 |
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| Structure | 
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