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TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
LigandBDBM279047
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50 21.0±n/a nM
Citation Juhl, K; Jessing, M; Langgård, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent US10766893 Publication Date 9/8/2020
More Info.:Get all data from this article,  Assay Method
 
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Name:Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms:61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1
Type:Protein
Mol. Mass.:61245.69
Organism:Homo sapiens (Human)
Description:P54750
Residue:535
Sequence:
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM279047
n/a
NameBDBM279047
Synonyms:5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine | US10034861, Example 77 | US10512632, Example 77 | US10766893, Example S77 | US10806718, Example 77 | US11026923, Example 77 | US11491140, Example 77 | US11634416, Example 77
TypeSmall organic molecule
Emp. Form.C24H25F3N6O
Mol. Mass.470.4901
SMILESCCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C
Structure
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