| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
|---|
| Ligand | BDBM279065 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 5.30±n/a nM |
|---|
| Citation |  Juhl, K; Jessing, M; Langgård, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent US10766893 Publication Date 9/8/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
|---|
| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
|---|
| Synonyms: | 3',5'-cyclic-AMP phosphodiesterase | 3',5'-cyclic-GMP phosphodiesterase | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Cam-PDE 1C | Hcam3 | PDE1C | PDE1C_HUMAN | Phosphodiesterase 1 | Phosphodiesterase 1C | Phosphodiesterase, PDE1/PDE5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 80778.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14123 |
|---|
| Residue: | 709 |
|---|
| Sequence: | MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR
SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR
LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE
QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLR
HFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
|
|
|
|---|
| BDBM279065 |
|---|
| n/a |
|---|
| Name | BDBM279065 |
|---|
| Synonyms: | 1-isopropyl-5-(2-methoxy-3-pyridyl)-N-[(6-methoxy-3-pyridyl)methyl]-3-methyl-pyrazolo[4,3-b]pyridin-7-amine | US10034861, Example 96 | US10512632, Example 96 | US10766893, Example S96 | US10806718, Example 96 | US11026923, Example 96 | US11491140, Example 96 | US11634416, Example 96 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26N6O2 |
|---|
| Mol. Mass. | 418.4915 |
|---|
| SMILES | COc1ccc(CNc2cc(nc3c(C)nn(C(C)C)c23)-c2cccnc2OC)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
