| Reaction Details |
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 | Report a problem with these data |
| Target | Wee1-like protein kinase |
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| Ligand | BDBM462383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Activity Assay |
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| IC50 | 0.400±n/a nM |
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| Citation |  Burkamp, F; Rountree, JS; Treder, AP Wee-1 inhibiting pyrazolopyrimidinone compounds US Patent US10766902 Publication Date 9/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Wee1-like protein kinase |
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| Name: | Wee1-like protein kinase |
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| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71599.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1445054 |
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| Residue: | 646 |
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| Sequence: | MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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| BDBM462383 |
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| n/a |
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| Name | BDBM462383 |
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| Synonyms: | US10766902, Example 96 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N9O2S |
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| Mol. Mass. | 507.611 |
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| SMILES | CS(C)(=O)=Nc1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3cnn(c3)C3CCCCC3)nc12 |
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| Structure | 
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