Reaction Details |
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Target | Neprilysin |
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Ligand | BDBM299496 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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Ki | <1.00±n/a nM |
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Citation | Fleury, M; Beausoliel, A; Hughes, AD; Long, DD; Wilton, DA Neprilysin inhibitors US Patent US9593110 Publication Date 3/14/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Neprilysin |
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Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
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BDBM299496 |
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n/a |
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Name | BDBM299496 |
Synonyms: | (2S,4S)-5-(5′-Chloro-2′-fluorobiphenyl-4-yl)-2-ethoxymethyl-4-[(5-trifluoromethyl-1H-[1,2,4]triazole-3-carbonyl)amino]pentanoic Acid | US9593110, Example 6 |
Type | Small organic molecule |
Emp. Form. | C26H27ClF4N4O4 |
Mol. Mass. | 570.964 |
SMILES | CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(=O)OCC |r| |
Structure |
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