| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neprilysin |
|---|
| Ligand | BDBM299634 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| Ki | <1.00±n/a nM |
|---|
| Citation |  Fleury, M; Beausoliel, A; Hughes, AD; Long, DD; Wilton, DA Neprilysin inhibitors US Patent US9593110 Publication Date 3/14/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neprilysin |
|---|
| Name: | Neprilysin |
|---|
| Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85505.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08473 |
|---|
| Residue: | 750 |
|---|
| Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
|
|
|
|---|
| BDBM299634 |
|---|
| n/a |
|---|
| Name | BDBM299634 |
|---|
| Synonyms: | (2S,4S)-2-(Acetylaminomethyl)-5-(5′-chloro-2′-fluoro-biphenyl-4-yl)-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic Acid | US9593110, Example 28 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23ClFN5O4 |
|---|
| Mol. Mass. | 487.911 |
|---|
| SMILES | CC(=O)NC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
